Brain-derived neurotrophic factor is neuroprotective against human immunodeficiency virus-1 envelope proteins.

@article{Bachis2005BrainderivedNF,
  title={Brain-derived neurotrophic factor is neuroprotective against human immunodeficiency virus-1 envelope proteins.},
  author={Alessia Bachis and Italo Mocchetti},
  journal={Annals of the New York Academy of Sciences},
  year={2005},
  volume={1053},
  pages={
          247-57
        }
}
Human immunodeficiency virus type 1 (HIV-1)-positive patients in the late phase of infection develop AIDS dementia complex, an array of neurological complications that include extrapyramidal symptoms, cognitive impairments, and psychiatric disturbances. Brains of these patients exhibit brain injury. The HIV-1 envelope glycoprotein 120 (gp120) has been suggested to be a causal agent of neuronal loss; however, several strains of gp120 exist during the infection and the relative neurotoxic… CONTINUE READING
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