Brain-derived neurotrophic factor is a potential osteoclast stimulating factor in multiple myeloma.

@article{Sun2012BrainderivedNF,
  title={Brain-derived neurotrophic factor is a potential osteoclast stimulating factor in multiple myeloma.},
  author={Chun-yan Sun and Zhang-bo Chu and Xiao-mei She and Lu Zhang and Lei Chen and Li-Sha Ai and Yu Cheng Hu},
  journal={International journal of cancer},
  year={2012},
  volume={130 4},
  pages={827-36}
}
Multiple myeloma (MM) is characterized by accumulation of monoclonal plasma cells in the bone marrow and progression of lytic bone lesions. The mechanisms of enhanced bone resorption in patients with myeloma are not fully defined. We have previously identified the role of brain-derived neurotrophic factor (BDNF) in proliferation and migration of MM cells. In our study, we investigated whether BDNF was possibly involved in MM cell-induced osteolysis. We showed that BDNF was elevated in MM… CONTINUE READING
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