Brain-derived neurotrophic factor induces proliferation of human airway smooth muscle cells

@inproceedings{Aravamudan2012BrainderivedNF,
  title={Brain-derived neurotrophic factor induces proliferation of human airway smooth muscle cells},
  author={Bharathi Aravamudan and Michael Allen Thompson and Christina M. Pabelick and Y S Prakash},
  booktitle={Journal of cellular and molecular medicine},
  year={2012}
}
Airway diseases such as asthma involve increased airway smooth muscle (ASM) contractility and remodelling via enhanced proliferation. Neurotrophins (NTs) such as brain-derived neurotrophic factor (BDNF), well-known in the nervous system, can regulate Ca(2+) signalling, and interact with cytokines in contributing to airway hyperreactivity. In this study, we determined whether and how BDNF regulates human ASM cell proliferation in the presence of inflammation, thus testing its potential role in… CONTINUE READING