Brain-derived neurotrophic factor increases the electrical activity of pars compacta dopamine neurons in vivo.

@article{Shen1994BrainderivedNF,
  title={Brain-derived neurotrophic factor increases the electrical activity of pars compacta dopamine neurons in vivo.},
  author={Richard Y W Shen and Charles Anthony Altar and Louis A. Chiodo},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1994},
  volume={91 19},
  pages={
          8920-4
        }
}
Chronic infusions of brain-derived neurotrophic factor (BDNF) immediately above the substantia nigra augment spontaneous locomotion, rotational behavior, and striatal dopamine (DA) turnover, indicating that BDNF increases functions of the nigrostriatal DA system. Because the function of the nigrostriatal DA system is related to the electrical activity of DA neurons, we investigated the effect of BDNF on the electrical activity of DA neurons in the substantia nigra pars compacta in vivo. Chronic… CONTINUE READING
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