Brain-derived neurotrophic factor in mood disorders and antidepressant treatments

  title={Brain-derived neurotrophic factor in mood disorders and antidepressant treatments},
  author={Eero Castr{\'e}n and Masami Kojima},
  journal={Neurobiology of Disease},

Brain-Derived Neurotrophic Factor Signaling in Depression and Antidepressant Action

Interplay of Brain-Derived Neurotrophic Factor and Cytokines in Schizophrenia

Abstract Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophin family and plays an important role in neuroplasticity, differentiation and survival of neurons, as well as their

The Role of BDNF on Neural Plasticity in Depression

The studies reviewed here may suggest new possible targets for antidepressant drugs such as neurotrophins, their receptors, and relevant signaling pathways, and agents facilitating the activation of gene expression and increasing the transcription of neurotrophic factors in the brain.

Plasma Levels of Brain-Derived Neurotrophic Factor and S100B in Relation to Antidepressant Response to Ketamine

Findings do not support the hypothesis that ketamine treatment increases BDNF plasma levels in MDD patients and the change of plasma mBDNF levels was positively correlated with the improvement of MADRS score after 1–2 weeks of open-label ketamines treatment.

Role of BDNF in the pathophysiology and treatment of depression: Activity‐dependent effects distinguish rapid‐acting antidepressants

This work demonstrates that stress and depression are associated with atrophy of neurons and reduced synaptic connectivity in brain regions such as the hippocampus and prefrontal cortex that contribute to depressive behaviors, and conversely that antidepressant treatment can reverse these deficits.

Unfolding the Role of BDNF as a Biomarker for Treatment of Depression.

The role of BDNF in the pathogenesis of depression and treatment of this disorder with antidepressants is supported and BDNF impairment in relation to depression, neuroplasticity, and neurogenesis is explored, showing positive response in the management of depression.

Neurotrophic factors and neuroplasticity pathways in the pathophysiology and treatment of depression

It is advocated that future development of antidepressants should be based on the neurotrophin theory, because mounting evidence suggests that antidepressant treatment may exert its beneficial effects by enhancing trophic signaling on neuronal and synaptic plasticity.

BDNF pro-peptide: physiological mechanisms and implications for depression

It is demonstrated that the BDNF pro-peptide is a biologically important synaptic modulator and is associated with MDD, particularly in males, and levels were significantly lower in patients with major depressive disorder (MDD) than in controls.



Mice with altered BDNF signaling as models for mood disorders and antidepressant effects

A review of studies where various mouse models with increased or decreased BDNF levels or TrkB signaling were used to evaluate the role of BDNF signaling in depression-like behavior in mice shows that BDNF plays a critical role in the mechanisms underlying the actions of AD.

A Neurotrophic Model for Stress-Related Mood Disorders

New insights into BDNF function in depression and anxiety

BDNF may be a target of antidepressants, but not the sole mediator of depression or anxiety, and as the precursor proBDNF and the mature protein mBDNF can elicit opposite effects on cellular functions, the impact of proBD NF and its cleavage on mood should be considered.

Neurotrophins and psychiatric disorders.

  • E. Castrén
  • Psychology, Biology
    Handbook of experimental pharmacology
  • 2014
Neurotrophins should not be seen as happiness factors but as critical tools in the process where brain networks are optimally tuned to environment, and it is against this background that the effects of neurotrophins on neuropsychiatric disorders should be looked at.

Brain-Derived Neurotrophic Factor Produces Antidepressant Effects in Behavioral Models of Depression

The hypothesis that BDNF in the hippocampus produces an antidepressant effect in behavioral models of depression, the learned helplessness (LH) and forced swim test (FST) paradigms is tested and provides further support for the hypothesis thatBDNF contributes to the therapeutic action of antidepressant treatment.

Role of Brain-Derived Neurotrophic Factor in the Aetiology of Depression

The network hypothesis of depression suggests that antidepressant drugs should not be used alone but should always be combined with rehabilitation to guide the plastic networks within the brain.

Alterations of serum levels of brain-derived neurotrophic factor (BDNF) in depressed patients with or without antidepressants

Neurotrophins and depression.

  • C. Altar
  • Biology, Psychology
    Trends in pharmacological sciences
  • 1999

Chronic Duloxetine Treatment Induces Specific Changes in the Expression of BDNF Transcripts and in the Subcellular Localization of the Neurotrophin Protein

The data suggest that chronic treatment with the novel antidepressant duloxetine not only produces a marked upregulation of BDNF mRNA and protein, but may also affect the subcellular redistribution of the neurotrophin to improve synaptic plasticity and cognitive function that are defective in depressed subjects.

Brain-Derived Neurotrophic Factor Val66Met Polymorphism and Antidepressant Efficacy of Ketamine in Depressed Patients