Brain-derived neurotrophic factor in mood disorders and antidepressant treatments

@article{Castrn2017BrainderivedNF,
  title={Brain-derived neurotrophic factor in mood disorders and antidepressant treatments},
  author={Eero Castr{\'e}n and Masami Kojima},
  journal={Neurobiology of Disease},
  year={2017},
  volume={97},
  pages={119-126}
}
Brain-Derived Neurotrophic Factor Signaling in Depression and Antidepressant Action
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TLDR
The studies reviewed here may suggest new possible targets for antidepressant drugs such as neurotrophins, their receptors, and relevant signaling pathways, and agents facilitating the activation of gene expression and increasing the transcription of neurotrophic factors in the brain.
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TLDR
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TLDR
This work demonstrates that stress and depression are associated with atrophy of neurons and reduced synaptic connectivity in brain regions such as the hippocampus and prefrontal cortex that contribute to depressive behaviors, and conversely that antidepressant treatment can reverse these deficits.
Neurotrophic factors and neuroplasticity pathways in the pathophysiology and treatment of depression
TLDR
It is advocated that future development of antidepressants should be based on the neurotrophin theory, because mounting evidence suggests that antidepressant treatment may exert its beneficial effects by enhancing trophic signaling on neuronal and synaptic plasticity.
BDNF pro-peptide: physiological mechanisms and implications for depression
TLDR
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Glucocorticoid and brain-derived neurotrophic factor relationship: a brief investigation into the model of depression by chronic administration of corticosterone
TLDR
This work evaluated serum corticosterone levels, adrenal/body weight ratio, as well as glucocorticoid receptor and brain-derived neurotrophic factor protein expression and its receptor, tropomyosin-receptor kinase B, and found a positive correlation between the expression of glucoc Corticosterone receptor and tyrosine-recept kinases B.
The Role of BDNF in the Neuroimmune Axis Regulation of Mood Disorders
TLDR
This review focuses on the recent progress of BDNF in influencing mood disorders, by participating in alterations of the neuroimmune axis, and may provide evidence for future studies in this field.
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