Brain-derived neurotrophic factor in mood disorders and antidepressant treatments
@article{astrn2017BrainderivedNF, title={Brain-derived neurotrophic factor in mood disorders and antidepressant treatments}, author={E. Ċastr{\'e}n and M. Kojima}, journal={Neurobiology of Disease}, year={2017}, volume={97}, pages={119-126} }
Levels of brain-derived neurotrophic factor (BDNF) are reduced in the brain and serum of depressed patients and at least the reduction in serum levels is reversible upon successful treatment. These data, together with a wealth of reports using different animal models with depression-like behavior or manipulation of expression of BDNF or its receptor TrkB have implicated BDNF in the pathophysiology of depression as well as in the mechanism of action of antidepressant treatments. Recent findings… CONTINUE READING
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References
SHOWING 1-10 OF 162 REFERENCES
Mice with altered BDNF signaling as models for mood disorders and antidepressant effects
- Psychology, Medicine
- Front. Behav. Neurosci.
- 2014
- 61
- PDF
A Neurotrophic Model for Stress-Related Mood Disorders
- Psychology, Medicine
- Biological Psychiatry
- 2006
- 2,662
Brain-Derived Neurotrophic Factor and Neuropsychiatric Disorders
- Medicine
- Pharmacological Reviews
- 2012
- 824
- PDF
Neurotrophins and psychiatric disorders.
- Medicine
- Handbook of experimental pharmacology
- 2014
- 93
- Highly Influential
New insights into BDNF function in depression and anxiety
- Psychology, Medicine
- Nature Neuroscience
- 2007
- 876
Role of Brain-Derived Neurotrophic Factor in the Aetiology of Depression
- Psychology, Medicine
- CNS drugs
- 2010
- 86
Brain-Derived Neurotrophic Factor Produces Antidepressant Effects in Behavioral Models of Depression
- Psychology, Medicine
- The Journal of Neuroscience
- 2002
- 1,440
- PDF
Peripheral brain-derived neurotrophic factor in schizophrenia and the role of antipsychotics: meta-analysis and implications
- Psychology, Medicine
- Molecular Psychiatry
- 2014
- 134
- PDF
Alterations of serum levels of brain-derived neurotrophic factor (BDNF) in depressed patients with or without antidepressants
- Psychology, Medicine
- Biological Psychiatry
- 2003
- 1,021