Brain-derived neurotrophic factor enhances striatal neuropeptide expression in both the intact and the dopamine-depleted rat striatum.

@article{Sauer1994BrainderivedNF,
  title={Brain-derived neurotrophic factor enhances striatal neuropeptide expression in both the intact and the dopamine-depleted rat striatum.},
  author={Hansjorg Sauer and Kenneth Campbell and Stanley J. Wiegand and Ronald M. Lindsay and Anders Bj{\"o}rklund},
  journal={Neuroreport},
  year={1994},
  volume={5 5},
  pages={609-12}
}
In order to elucidate the importance of the striatal GABAergic neurones in mediating functional effects of exogenously applied brain-derived neurotrophic factor (BDNF) in the basal ganglia, we performed daily injections of BDNF or vehicle into the dopamine-depleted striatum of unilaterally 6-hydroxydopamine-lesioned rats for 1 week. In situ hybridization revealed that BDNF exacerbated the lesion-induced up-regulation of preproenkephalin (PPE) mRNA, and completely reversed the lesion-induced… CONTINUE READING