Brain-derived neurotrophic factor and neurotrophin 3 in schizophrenic psychoses.

  title={Brain-derived neurotrophic factor and neurotrophin 3 in schizophrenic psychoses.},
  author={N{\'u}ria Durany and Thomas Michel and Robert Z{\"o}chling and K. W. Boissl and Felix F. Cruz-S{\'a}nchez and Peter Franz Riederer and Johannes Thome},
  journal={Schizophrenia research},
  volume={52 1-2},
Disturbed neural development has been postulated as a crucial factor in the pathophysiology of schizophrenic psychoses. The neurobiochemical basis for such changes of cytoarchitecture and changed neural plasticity could involve an alteration in the regulation of neurotrophic factors. In order to test this hypothesis, BDNF and NT-3 levels in post-mortem brain tissue from schizophrenic patients were determined by ELISA. There was a significant increase in BDNF concentrations in cortical areas and… CONTINUE READING
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