Brain-derived neurotrophic factor Val66met polymorphism and plasma levels in road traffic accident survivors.

@article{Heuvel2016BrainderivedNF,
  title={Brain-derived neurotrophic factor Val66met polymorphism and plasma levels in road traffic accident survivors.},
  author={Leigh L van den Heuvel and Sharain Suliman and Stefanie Malan-M{\"u}ller and Sian Megan Joanna Hemmings and Soraya Seedat},
  journal={Anxiety, stress, and coping},
  year={2016},
  volume={29 6},
  pages={
          616-29
        }
}
BACKGROUND Alterations in brain-derived neurotrophic factor (BDNF) expression and release may play a role in the pathogenesis of post-traumatic stress disorder (PTSD). DESIGN This study evaluated road traffic accident (RTA) survivors to determine whether PTSD and trauma-related factors were associated with plasma BDNF levels and BDNF Val66Met carrier status following RTA exposure. METHODS One hundred and twenty-three RTA survivors (mean age 33.2 years, SD = 10.6 years; 56.9% male) were… CONTINUE READING