Brain-derived neurotrophic factor Val66Met and psychiatric disorders: meta-analysis of case-control studies confirm association to substance-related disorders, eating disorders, and schizophrenia.

@article{Gratacs2007BrainderivedNF,
  title={Brain-derived neurotrophic factor Val66Met and psychiatric disorders: meta-analysis of case-control studies confirm association to substance-related disorders, eating disorders, and schizophrenia.},
  author={M{\'o}nica Gratac{\'o}s and Juan R. Gonz{\'a}lez and Josep Maria Mercader and Rafael de Cid and Mikel Urretavizcaya and Xavier Estivill},
  journal={Biological psychiatry},
  year={2007},
  volume={61 7},
  pages={911-22}
}
BACKGROUND There is an increasing recognition that the pathophysiology of mental disorders could be the result of deregulation of synaptic plasticity with alterations of neurotrophins. The valine (Val)66-to-methionine (Met) variant, located in the pro brain-derived neurotrophic factor (BDNF) sequence, has been extensively studied through linkage and association approaches in several psychiatric disorders. METHODS We performed a meta-analysis restricted to individual case-control studies in… CONTINUE READING
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