Brain-derived neurotrophic factor (BDNF) ameliorates the suppression of thyroid hormone-induced granule cell neurite extension by hexabromocyclododecane (HBCD).

@article{Ibhazehiebo2011BrainderivedNF,
  title={Brain-derived neurotrophic factor (BDNF) ameliorates the suppression of thyroid hormone-induced granule cell neurite extension by hexabromocyclododecane (HBCD).},
  author={Kingsley Ibhazehiebo and Toshiharu Iwasaki and Ming Xu and Noriaki Shimokawa and Noriyuki Koibuchi},
  journal={Neuroscience letters},
  year={2011},
  volume={493 1-2},
  pages={1-7}
}
Thyroid hormone (TH) plays an essential role in growth and differentiation of the central nervous system. Deficiency of TH during perinatal period results in abnormal brain development known as cretinism in human. We recently reported that an environmental chemical 1,2,5,6,9,10-α-hexabromocyclododecane (HBCD) suppressed TH receptor (TR)-mediated transcription. To examine the effect of HBCD on cerebellar granule cells, we used purified rat cerebellar granule cells in reaggregate culture. Low… CONTINUE READING