Brain-derived neurotrophic factor (BDNF) and its precursor proBDNF as diagnostic biomarkers for major depressive disorder and bipolar disorder

  • Kenji Hashimoto
  • Published 2014 in
    European Archives of Psychiatry and Clinical…


signal peptide, proBDNF (~32 kDa) is converted to mature BDNF by extracellular proteases. It was initially thought that only secreted, mature BDNF was biologically active, and that proBDNF, which localizes intracellularly, served as an inactive precursor. However, accumulating evidence shows that both proBDNF and mature BDNF are active, eliciting opposing… (More)
DOI: 10.1007/s00406-014-0557-x