Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism in schizophrenia is associated with age at onset and symptoms.

@article{Numata2006BrainderivedNF,
  title={Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism in schizophrenia is associated with age at onset and symptoms.},
  author={Shusuke Numata and Shu-Ichi Ueno and Jun-Ichi Iga and Ken Ichi Yamauchi and Song Hongwei and Koji Ohta and Sawako Kinouchi and Sumiko Shibuya-Tayoshi and Shin'ya Tayoshi and Michitaka Aono and Naomi Kameoka and Satsuki Sumitani and Masahito Tomotake and Yasuhiro Kaneda and Takahide Taniguchi and Yasuhito Ishimoto and Tetsuro Ohmori},
  journal={Neuroscience letters},
  year={2006},
  volume={401 1-2},
  pages={1-5}
}
Brain-derived neurotrophic factor (BDNF) is a neurotrophic factor that promotes several functions of neurons and modulates neurotransmissions. It has been reported that there are alterations of BDNF levels in schizophrenic brains and that BDNF gene expressional changes would be responsible for the etiology of schizophrenia. Recent studies have shown that a variation of BDNF gene (Val66Met polymorphism) affects the function of neurons, and is associated with several neurological and… CONTINUE READING

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