Brain derived metastatic prostate cancer DU-145 cells are effectively inhibited in vitro by guava (Psidium gujava L.) leaf extracts.

@article{Chen2007BrainDM,
  title={Brain derived metastatic prostate cancer DU-145 cells are effectively inhibited in vitro by guava (Psidium gujava L.) leaf extracts.},
  author={Kuan-Chou Chen and Chiu-Lan Hsieh and C Peng and Hsiu-Mei Hsieh-Li and H N Chiang and Kuan-Dar Huang and Robert Y. Peng},
  journal={Nutrition and cancer},
  year={2007},
  volume={58 1},
  pages={93-106}
}
The aqueous extract of Psidium guajava L. (PE) inhibited the cancer cell DU-145 in a dose- and time-dependent manner. At 1.0 mg/mL, PE reduced the viability of PCa DU-145 (the androgen independent PCa cells) to 36.1 and 3.59%, respectively after 48 h and 72 h of incubations. The absolute cell viability suppressing capability (VSC)(AC) could reach 262.5 cells-mL-h/mg on exposure to PE for 72 h, corresponding to the safe ranges, i.e. the percent viability suppressing rates (PVSR) of 2.72 and 2.41… CONTINUE READING