Brain-derived gangliosides regulate the cytokine production and proliferation of activated T cells.

@article{Irani1996BrainderivedGR,
  title={Brain-derived gangliosides regulate the cytokine production and proliferation of activated T cells.},
  author={David N. Irani and Kuo I Lin and Diane E Griffin},
  journal={Journal of immunology},
  year={1996},
  volume={157 10},
  pages={4333-40}
}
Gangliosides may regulate the activity of the immune system in vivo, particularly within tissues such as neoplasms or the central nervous system, where they are most abundant. However, the specific mechanisms by which gangliosides modulate immune function remain incompletely understood. We have characterized the effects that brain-derived gangliosides have on specific steps of the T cell activation process in vitro. Gangliosides inhibit T cell proliferation downstream from the early activation… CONTINUE READING
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