In the last decade, one of the most avidly studied compounds in the central nervous system (CNS) has been the neurotrophin BDNF. Although historically it had been studied in the context of development, where it plays numerous critical roles, more recent studies have shown striking actions on a number of pathways and processes that are critical for normal… CONTINUE READING
Figure 5. Effects of BDNF in an animal with chronic seizures (i.e., epileptic) and mossy fiber sprouting. Stimulation of the hilus to activate mossy fibers in an epileptic rat with mossy fiber sprouting (Top) evoked an antidromic population spike (arrow) followed by an orthodromic population spike (arrowhead). After BDNF was added to the buffer, the same stimulus evoked multiple population spikes (Top, center) and subsequently spontaneous population spike occur in bursts (Top, right). In contrast, only an antidromic spike was evoked by hilar stimulation in a slice from a control rat without sprouting (Bottom), even after supramaximal stimuli, and even after prolonged exposure to BDNF. No spontaneous activity occurred. Calibration for recordings from epileptic tissue, 10 msec; for control recordings, 5 msec (Scharfman et al., 1999).