Brain delivery of olanzapine by intranasal administration of transfersomal vesicles.

@article{Salama2012BrainDO,
  title={Brain delivery of olanzapine by intranasal administration of transfersomal vesicles.},
  author={Hamed A. Salama and Azza A Mahmoud and Amany O. Kamel and Mayssa Abdel Hady and Gehanne A. S. Awad},
  journal={Journal of liposome research},
  year={2012},
  volume={22 4},
  pages={336-45}
}
The aim of this study was to investigate the presence of a possible direct correlation between vesicle elasticity and the amount of drug reaching the brain intranasally. Therefore, transfersomes were developed using phosphatidylcholine (PC) as the lipid matrix and sodium deoxycholate (SDC), Span® 60, Cremophor® EL, Brij® 58, and Brij® 72 as surfactants. The influence of the type of surfactant and PC-to-surfactant ratio on vesicle morphology, size, membrane elasticity, drug entrapment, and in… CONTINUE READING
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