Brain death induces apoptosis in donor liver of the rat.

  title={Brain death induces apoptosis in donor liver of the rat.},
  author={Joost A B van der Hoeven and Han Moshage and Theo A. Schuurs and Mijntje Nijboer and Reinout van Schilfgaarde and Rutger J Ploeg},
  volume={76 8},
BACKGROUND A difference in short- and long-term function between living-related and cadaveric donor organs is consistently shown in kidney- and liver-transplant studies. We hypothesize that this is caused by induction of apoptosis and inflammation of the potential graft because of the phase of brain death (BD) in the cadaveric donor that predisposes for additional transplant injury. Previously, we have shown inflammation in the liver of brain-dead donors by increased expression of cell adhesion… CONTINUE READING


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