Brain death induced renal injury

@article{Westendorp2011BrainDI,
  title={Brain death induced renal injury},
  author={Welmoet H. Westendorp and Henri G. D. Leuvenink and Rutger J Ploeg},
  journal={Current Opinion in Organ Transplantation},
  year={2011},
  volume={16},
  pages={151–156}
}
Purpose of reviewThe considerable demand in kidney transplantation against a persisting organ donor shortage has forced most centers to nowadays accept of suboptimal donor kidneys. Recent findingsDespite the substantial increase in the past decade in kidney transplantation with grafts retrieved from living donors and after donation from deceased brain dead (DBD) and extended criteria donation (ECD) donors, the supply of donor kidneys still does not meet the actual numbers needed. Moreover… 
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49 Citations
Background Citations
20
Results Citations
1

49 Citations

Citation Type

Citation Type

Brain death: from inflammation to metabolic changes
TLDR
It is found that whilst the kidney is suffering from a decrease in oxygen delivery and blood flow, the liver is actively consuming oxygen with no change in blood delivery.
Kidney Transplantation From Brain-Dead Donors: Initial Experience in China.
New strategies to optimize kidney recovery and preservation in transplantation
TLDR
Overall, a combination of therapeutic approaches seem to provide the best outcome, but preclinical studies using relevant models are needed before these approaches can be incorporated into clinical practice.
Complement‐mediated inflammation and injury in brain dead organ donors
The Physiology of Brain Death and Organ Donor Management
TLDR
There is a significant opportunity for enhancing donor multi-organ function and improving organ utilization with appropriate PICU management and general and organ specific donor management strategies and logistic considerations are discussed.
C1-Inhibitor Treatment Decreases Renal Injury in an Established Brain-Dead Rat Model
TLDR
Targeting complement activation after the induction of brain death reduced renal inflammation and improved renal function before transplantation, therefore, strategies targeting complement activation in human BD donors might clinically improve donor organ viability and renal allograft survival.
Renal Delivery of Pharmacologic Agents During Machine Perfusion to Prevent Ischaemia-Reperfusion Injury: From Murine Model to Clinical Trials
TLDR
An overview of the current knowledge of new preservation strategies by machine perfusions and pharmacological interventions at different timing possibilities: in the organ donor, ex-vivo during perfusion machine reconditioning or after implementation in the recipient is provided.
Is Brain-Dead Donor Fluid Therapy With Colloids Associated With Better Kidney Grafts?
  • Niko Limnell, A. Schramko
  • Medicine
    Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation
  • 2018
TLDR
The results suggest that donor fluid therapy including colloids could be beneficial instead of harmful compared with treatment with crystalloids alone, and needs to be evaluated in prospective studies.
Ischemia as a factor affecting innate immune responses in kidney transplantation
TLDR
The role of the innate immune system in ischemia-induced renal injury in kidneys procured for transplantation is described and the key role of pattern recognition receptors in immune responses to ischemIA is described.
Renal effects of exendin-4 in an animal model of brain death
TLDR
It is suggested that exendin-4 administration in BD rats reduces BD-induced kidney damage by decreasing the expression of oxidative stress genes and increasing theexpression of Bcl2.
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References

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TLDR
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