Brain damage of the preterm infant: new insights into the role of inflammation.

@article{Steenwinckel2014BrainDO,
  title={Brain damage of the preterm infant: new insights into the role of inflammation.},
  author={Juliette Van Steenwinckel and A L Schang and St{\'e}phanie Sigaut and Vibol Chhor and V Degos and Henrik Hagberg and Olivier Baud and Bobbi Fleiss and Pierre Gressens},
  journal={Biochemical Society transactions},
  year={2014},
  volume={42 2},
  pages={
          557-63
        }
}
Epidemiological studies have shown a strong association between perinatal infection/inflammation and brain damage in preterm infants and/or neurological handicap in survivors. Experimental studies have shown a causal effect of infection/inflammation on perinatal brain damage. Infection including inflammatory factors can disrupt programmes of brain development and, in particular, induce death and/or blockade of oligodendrocyte maturation, leading to myelin defects. Alternatively, in the so… CONTINUE READING
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