Brain cytochrome oxidase activity of synaptic and nonsynaptic mitochondria during aging.

@article{Gorini1989BrainCO,
  title={Brain cytochrome oxidase activity of synaptic and nonsynaptic mitochondria during aging.},
  author={Antonella Gorini and Roberto Arnaboldi and Barbara Ghigini and Roberto Federico Villa},
  journal={Basic and applied histochemistry},
  year={1989},
  volume={33 2},
  pages={139-45}
}
The activity of cytochrome c oxidase was studied in aging brain on non-synaptic and intra-synaptic mitochondria from frontal cerebral cortex, hippocampus and striatum of 4, 8, 12, 16, 20 and 24 month-old Sprague-Dawley rats. Specific activities of cytochrome oxidase were significantly higher in light synaptic mitochondria than in non-synaptic or heavy ones at all the ages examined. However, enzyme activity in light mitochondria from cerebral cortex remains unchanged during aging, being… CONTINUE READING

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