Brain cyclic AMP and memory in mice.

  title={Brain cyclic AMP and memory in mice.},
  author={C T Randt and Martin E. Judge and Kenneth A Bonnet and David Quartermain},
  journal={Pharmacology, biochemistry, and behavior},
  volume={17 4},
A phosphodiesterase inhibitor 4-(3-cyclopentyloxy-4-methoxyphenyl)-2-pyrrolidone (Rolipram, 10 mg/kg IP) administered immediately, but not 3 hr post-training, reversed an amnesia for an inhibitory avoidance response induced by the protein synthesis inhibitor anisomycin. Immediate post-training administration of Rolipram also enhanced retention for a weakly learned avoidance response. Unshocked animals did not show increased test latencies thus ruling out conditioned aversion as an explanation… CONTINUE READING
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