Brain corticotropin-releasing factor acts as inhibitor of stress-induced gastric erosion in rats.

@article{Shibasaki1990BrainCF,
  title={Brain corticotropin-releasing factor acts as inhibitor of stress-induced gastric erosion in rats.},
  author={Tamotsu Shibasaki and Naoko Yamauchi and Masanaka Hotta and Akiko Masuda and Hideto Oono and Ichiji Wakabayashi and Nicholas Ling and Hiroshi Demura},
  journal={Life sciences},
  year={1990},
  volume={47 11},
  pages={
          925-32
        }
}
Gastric lesions are known to be caused by stress. Corticotropin-releasing factor (CRF) is a key peptide initiating various stress response. This study was designed to investigate how brain CRF is involved in the occurrence of stress-induced gastric erosion in rats. Intracerebroventricular (icv) administration of CRF suppressed the occurrence of gastric erosion induced by water-immersion restraint stress, and its suppressive effect was blocked by coadministration of a CRF receptor antagonist in… CONTINUE READING