Brain corticosteroid receptor balance in health and disease.

@article{deKloet1998BrainCR,
  title={Brain corticosteroid receptor balance in health and disease.},
  author={E. Ron de Kloet and Erno Vreugdenhil and Melly S. Oitzl and Marian Jo{\"e}ls},
  journal={Endocrine reviews},
  year={1998},
  volume={19 3},
  pages={
          269-301
        }
}
In this review, we have described the function of MR and GR in hippocampal neurons. The balance in actions mediated by the two corticosteroid receptor types in these neurons appears critical for neuronal excitability, stress responsiveness, and behavioral adaptation. Dysregulation of this MR/GR balance brings neurons in a vulnerable state with consequences for regulation of the stress response and enhanced vulnerability to disease in genetically predisposed individuals. The following specific… Expand
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References

SHOWING 1-10 OF 471 REFERENCES
Feedback action and tonic influence of corticosteroids on brain function: A concept arising from the heterogeneity of brain receptor systems
TLDR
Two types of corticosteroid receptors can be distinguished in rat brain and the CR has its predominant localization in neurons of the septo-hippocampal complex and has a ten-fold higher affinity for CORT than that of the GR, which mediates a tonic influence exerted with stringent specificity by CORT on hippocampus-associated functions. Expand
Mineralocorticoid and glucocorticoid receptors in the brain. Implications for ion permeability and transmitter systems
TLDR
The ratio of MR/GR occupation is an important factor determining the net effect of corticosteroid hormones in the brain, and how coordinated MR- and GR-mediated effects control neuronal communication under various physiological and pathological conditions will be a challenge for future research. Expand
Corticosterone and serotonergic neurotransmission in the hippocampus: functional implications of central corticosteroid receptor diversity.
TLDR
It is proposed that the balance of MR/GR activation can be altered by chronic (stress-related) changes of corticosteroid concentrations, in combination with glucocorticoid feedback resistance, which would lead to a relative dominance of MR-mediated suppressive effects on the activity of the raphe-hippocampal system, which may be a biologically relevant aspect of depression. Expand
Corticosteroids and Hippocampal Plasticity
  • B. McEwen
  • Biology, Medicine
  • Annals of the New York Academy of Sciences
  • 1994
TLDR
Present information indicates that type II receptors inhibit LTP and may play a role in the degenerative changes in Ammon's horn, and type I receptors appear to play arole in containing programmed-cell death and the rate of neurogenesis. Expand
Corticosteroid receptor-dependent modulation of calcium currents in rat hippocampal CA1 neurons
TLDR
The data suggest that the changes in MR and GR occupation throughout the day, related to circadian and stress-induced corticosterone release, are linked to marked alterations in Ca currents, with small Ca currents in the morning and large currents inThe evening or after stress. Expand
Coordinative mineralocorticoid and glucocorticoid receptor-mediated control of responses to serotonin in rat hippocampus.
TLDR
Responses to 5HT in the hippocampal slice when not only MRs but also glucocorticoid receptors (GRs) were occupied were established, using either a combination of selective MR and GR ligands or different concentrations of the endogenous mixed agonist corticosterone. Expand
Stress, Glucocorticoids, and Damage to the Nervous System: The Current State of Confusion.
TLDR
An extensive literature demonstrates that glucocorticoids, the adrenal steroids secreted during stress, can have a broad range of deleterious effects in the brain, particularly in the hippocampus, a structure rich in corticosteroid receptors and particularly sensitive to GCs. Expand
Regulation of glucocorticoid and mineralocorticoid receptor mRNAs in the hippocampus of the maternally deprived infant rat
TLDR
The results indicate that corticoid receptors in the developing CA1 hippocampal region appear to be sensitive to circulating CS and suggest that the relative ratio of GR and MR in the CA1 region may contribute to the enhanced and sustained CS response seen after a mild stressor in deprived animals. Expand
Hippocampal Cell Responses in Mice with a Targeted Glucocorticoid Receptor Gene Disruption
TLDR
It appeared that in the animals homozygous for the genetic defect, the properties studied, i.e., the voltage-gated Ca currents and responses to serotonin and the cholinergic analog carbachol, resembled the effects observed in adrenalectomized mice, which may point to the necessity of functional GRs for the development of MR-induced actions. Expand
Antidepressants increase glucocorticoid and mineralocorticoid receptor mRNA expression in rat hippocampus in vivo.
TLDR
Examining whether acute or chronic treatment with antidepressant drugs, which potentiate endogenous monoamines by inhibiting their reuptake, affect hippocampal GR and MR mRNA expression in vivo finds that antidepressant drug administration elevates MR and GR mRNA Expression in hippocampus, but not parietal cortex, in a time-dependent manner. Expand
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