Brain-corticosteroid hormone dialogue: Slow and persistent

  title={Brain-corticosteroid hormone dialogue: Slow and persistent},
  author={E. Ronald de Kloet and Nynke Y. Rots and Alexander Rudolf Cools},
  journal={Cellular and Molecular Neurobiology},
1. The stress response system is shaped by genetic factors and life experiences, of which the effect of a neonatal life event is among the most persistent. Here we report studies focused on the “nature-nurture” question using rat lines genetically selected for extreme differences in dopamine phenotype as well as rats exposed as infants to the traumatic experience of maternal deprivation. 2. As key to the endocrine and behavioural adaptations occurring in these two animal models the hormone… CONTINUE READING
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