Brain cholesterol turnover required for geranylgeraniol production and learning in mice.

@article{Kotti2006BrainCT,
  title={Brain cholesterol turnover required for geranylgeraniol production and learning in mice.},
  author={Tiina J Kotti and Denise M O Ramirez and Brad E Pfeiffer and Kimberly M Huber and D. W. Russell},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2006},
  volume={103 10},
  pages={3869-74}
}
The mevalonate pathway produces cholesterol and nonsterol isoprenoids, such as geranylgeraniol. In the brain, a fraction of cholesterol is metabolized in neurons by the enzyme cholesterol 24-hydroxylase, and this depletion activates the mevalonate pathway. Brains from mice lacking 24-hydroxylase excrete cholesterol more slowly, and the tissue compensates by suppressing the mevalonate pathway. Here we report that this suppression causes a defect in learning. 24-Hydroxylase knockout mice exhibit… CONTINUE READING

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