Brain chemotherapy from the bench to the clinic: targeting neuronal survival with small molecule inhibitors of apoptosis.


Increasing evidence implicates aberrant apoptosis as a fundamental cause of neurodegenerative diseases. Thus elucidating the underlying causes of neuronal programmed cell death may foster the development of therapeutic interventions. Research in the last 15 years provided a solid foundation for understanding molecular mechanisms of neuronal apoptosis. This… (More)


6 Figures and Tables