Brain changes in schizophrenia. Volumetric MRI study of families multiply affected with schizophrenia--the Maudsley Family Study 5.

@article{Sharma1998BrainCI,
  title={Brain changes in schizophrenia. Volumetric MRI study of families multiply affected with schizophrenia--the Maudsley Family Study 5.},
  author={Tonmoy Sharma and Eric Lancaster and Dong-Soo Lee and Sh{\^o}n Lewis and Thordur Sigmundsson and Nori Takei and Hugh M.D. Gurling and Patrick Barta and Godfrey D. Pearlson and Robin Murray},
  journal={The British journal of psychiatry : the journal of mental science},
  year={1998},
  volume={173},
  pages={
          132-8
        }
}
BACKGROUND Structural brain abnormalities have been reported in schizophrenia. We tested the hypothesis that these abnormalities represented a marker for the genetic liability to schizophrenia in a sample of people with schizophrenia and their relatives from families multiply affected with the disorder. METHOD We compared 31 people with schizophrenia, 57 relatives and 39 unrelated control subjects. Volumetric measurement of brain structures was carried out using stereological principles from… CONTINUE READING

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