Brain-borne IL-1 adjusts glucoregulation and provides fuel support to astrocytes and neurons in an autocrine/paracrine manner

@article{Rey2016BrainborneIA,
  title={Brain-borne IL-1 adjusts glucoregulation and provides fuel support to astrocytes and neurons in an autocrine/paracrine manner},
  author={A. Mart́ın del Rey and M Verdenhalven and Andrea Carolin L{\"o}rwald and Clifford Meyer and Miriam Hernang{\'o}mez and Anke Randolf and Enrico Roggero and Andrew M Koenig and Johannes T. Heverhagen and Carmen Guaza and Hugo Oscar Besedovsky},
  journal={Molecular Psychiatry},
  year={2016},
  volume={21},
  pages={1309-1320}
}
It is still controversial which mediators regulate energy provision to activated neural cells, as insulin does in peripheral tissues. Interleukin-1β (IL-1β) may mediate this effect as it can affect glucoregulation, it is overexpressed in the ‘healthy’ brain during increased neuronal activity, and it supports high-energy demanding processes such as long-term… CONTINUE READING