Brain biopsies for neurodegenerative disease in children.

@article{Macgregor1978BrainBF,
  title={Brain biopsies for neurodegenerative disease in children.},
  author={Daune L Macgregor and R P Humphrey and David Lee Armstrong and Laurence Edward Becker},
  journal={The Journal of pediatrics},
  year={1978},
  volume={92 6},
  pages={
          903-5
        }
}
Brain biopsies for neurodegenerative disease performed at The Hospital for Sick Children, Toronto, over a 12-year period (1964 to 1976) were reviewed. Of 64 biopsies, major histologic abnormalities with diagnostic or prognostic significance comprised 39% of the total cases, minor abnormalities represented 13%, and 48% appeared normal. The procedure failed to provide prognostic assistance in 41%. With the advent for newer diagnostic techniques (enzyme assays and muscle, skin, peripheral nerve… CONTINUE READING
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