Brain biocompatibility of a biodegradable, controlled-release polymer in rats.

  title={Brain biocompatibility of a biodegradable, controlled-release polymer in rats.},
  author={Rafael John Tamargo and Jonathan I. Epstein and Carla S. Reinhard and Mark Chasin and Henry Brem},
  journal={Journal of biomedical materials research},
  volume={23 2},
We report the biocompatibility in the rat brain of a controlled-release, biodegradable polymer, the polyanhydride poly-[bis(p-carboxyphenoxy)propane-sebacic acid] copolymer (PCPP-SA) in a 20:80 formulation. The biodegradable polyanhydride can be used for drug delivery directly into the brain, circumventing the difficulties posed by the blood-brain barrier and avoiding the consequences of having to administer toxic doses systematically to reach therapeutic doses in the central nervous system… CONTINUE READING
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