Brain barrier systems: a new frontier in metal neurotoxicological research.

  title={Brain barrier systems: a new frontier in metal neurotoxicological research.},
  author={Wei Zheng and Michael Aschner and Jean-François Ghersi-Egea},
  journal={Toxicology and applied pharmacology},
  volume={192 1},
The concept of brain barriers or a brain barrier system embraces the blood-brain interface, referred to as the blood-brain barrier, and the blood-cerebrospinal fluid (CSF) interface, referred to as the blood-CSF barrier. These brain barriers protect the CNS against chemical insults, by different complementary mechanisms. Toxic metal molecules can either bypass these mechanisms or be sequestered in and therefore potentially deleterious to brain barriers. Supportive evidence suggests that damage… CONTINUE READING
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