Brain atrophy in relapsing multiple sclerosis: relationship to relapses, EDSS, and treatment with interferon beta-1a.

@article{Rudick2000BrainAI,
  title={Brain atrophy in relapsing multiple sclerosis: relationship to relapses, EDSS, and treatment with interferon beta-1a.},
  author={Richard A. Rudick and Elizabeth H. Fisher and Jar Chi Lee and Jeffrey T. Duda and Jack Simon},
  journal={Multiple sclerosis},
  year={2000},
  volume={6 6},
  pages={365-72}
}
Brain atrophy is a relevant surrogate marker of the disease process in multiple sclerosis (MS) because it represents the net effect of various pathological processes leading to brain tissue loss. There are various approaches to quantifying central nervous system atrophy in MS. We have focused on a normalized measure of whole brain atrophy, the brain parenchymal fraction (BPF). BPF is defined as the brain parenchymal volume, divided by the volume within the surface of the brain. We applied this… CONTINUE READING