Brain atrophy in primary progressive aphasia involves the cholinergic basal forebrain and Ayala's nucleus

@article{Teipel2014BrainAI,
  title={Brain atrophy in primary progressive aphasia involves the cholinergic basal forebrain and Ayala's nucleus},
  author={S. Teipel and W. Flatz and N. Ackl and M. Grothe and I. Kilimann and A. Bokde and L. Grinberg and E. Amaro and V. Kljajevic and E. Alho and C. Knels and A. Ebert and H. Heinsen and A. Danek},
  journal={Psychiatry Research: Neuroimaging},
  year={2014},
  volume={221},
  pages={187-194}
}
Primary progressive aphasia (PPA) is characterized by left hemispheric frontotemporal cortical atrophy. Evidence from anatomical studies suggests that the nucleus subputaminalis (NSP), a subnucleus of the cholinergic basal forebrain, may be involved in the pathological process of PPA. Therefore, we studied the pattern of cortical and basal forebrain atrophy in 10 patients with a clinical diagnosis of PPA and 18 healthy age-matched controls using high-resolution magnetic resonance imaging (MRI… Expand
Atrophy and structural covariance of the cholinergic basal forebrain in primary progressive aphasia
TLDR
The findings agree with the neuroanatomically proposed involvement of the cholinergic BF, particularly the NSP, in PPA syndromes and find a shift from a structural covariance of the BF with left hemispheric cortical areas in healthy aging towards right hemispherical cortical areas of PPA. Expand
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The demonstration of cholinergic denervation with an anatomy that fits the clinical picture suggests that cholinerg treatment is justified in patients with PPA who have positive AD biomarkers. Expand
Cholinergic Neurons in Nucleus Subputaminalis in Primary Progressive Aphasia
  • H. Hamodat, J. Fisk, S. Darvesh
  • Medicine, Biology
  • Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques
  • 2019
TLDR
Regardless of underlying pathology, all cases presenting with PPA showed a marked loss of cholinergic neurons in the NSP, providing further evidence for the importance of this nucleus in language function. Expand
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To conclude, in the authors' sample of PPA patients, LV but not SV was associated with cholinergic depletion, and BF atrophy in PPA does not imply cholinergy depletion. Expand
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Abstract Whilst initial anatomical studies of frontotemporal dementia focussed on cortical involvement, the relevance of subcortical structures to the pathophysiology of frontotemporal dementia hasExpand
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