Brain angiotensin II, an important stress hormone: regulatory sites and therapeutic opportunities.

@article{Saavedra2004BrainAI,
  title={Brain angiotensin II, an important stress hormone: regulatory sites and therapeutic opportunities.},
  author={J M Saavedra and Hiromichi Ando and I Armando and Gustavo Baiardi and Claudia Bregonzio and Miroslava Jezova and Jin Zhou},
  journal={Annals of the New York Academy of Sciences},
  year={2004},
  volume={1018},
  pages={76-84}
}
The presence of a brain Angiotensin II (Ang II) system, separated from and physiologically integrated with the peripheral, circulating renin-angiotensin system, is firmly established. Ang II is made in the brain and activates specific brain AT(1) receptors to regulate thirst and fluid metabolism. Some AT(1) receptors are located outside the blood-brain barrier and are sensitive to brain and circulating Ang II. Other AT(1) receptors, located inside the blood-brain barrier, respond to stimulation… CONTINUE READING
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