Brain and whole-body imaging in rhesus monkeys of 11C-NOP-1A, a promising PET radioligand for nociceptin/orphanin FQ peptide receptors.

@article{Kimura2011BrainAW,
  title={Brain and whole-body imaging in rhesus monkeys of 11C-NOP-1A, a promising PET radioligand for nociceptin/orphanin FQ peptide receptors.},
  author={Yasuyuki Kimura and Masahiro Fujita and Jinsoo Hong and Talakad G. Lohith and Robert L. Gladding and Sami S. Zoghbi and Johannes A Tauscher and Nancy A. Goebl and Karen S Rash and Zhaogen Chen and Concepci{\'o}n Pedregal and Vanessa N. Barth and Victor W. Pike and Robert B. Innis},
  journal={Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  year={2011},
  volume={52 10},
  pages={1638-45}
}
UNLABELLED Our laboratory developed (S)-3-(2'-fluoro-6',7'-dihydrospiro[piperidine-4,4'-thieno[3,2-c]pyran]-1-yl)-2-(2-fluorobenzyl)-N-methylpropanamide ((11)C-NOP-1A), a new radioligand for the nociceptin/orphanin FQ peptide (NOP) receptor, with high affinity (K(i), 0.15 nM) and appropriate lipophilicity (measured logD, 3.4) for PET brain imaging. Here, we assessed the utility of (11)C-NOP-1A for quantifying NOP receptors in the monkey brain and estimated the radiation safety profile of this… CONTINUE READING
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