Brain and ventricular volumetric changes in frontotemporal lobar degeneration over 1 year.

@article{Knopman2009BrainAV,
  title={Brain and ventricular volumetric changes in frontotemporal lobar degeneration over 1 year.},
  author={Davis S. Knopman and Clifford R. Jack and Joel H. Kramer and Bradley F. Boeve and Richard J. Caselli and Neill R. Graff-Radford and Mario F. Mendez and Bruce L. Miller and Nathaniel D Mercaldo},
  journal={Neurology},
  year={2009},
  volume={72 21},
  pages={1843-9}
}
BACKGROUND Measurement of volumetric changes with MR might be a useful surrogate endpoint for clinical trials in frontotemporal lobar degeneration (FTLD). Because there is only limited longitudinal imaging data currently available, we measured the rate of change over 1 year of whole brain volume (WBV) and ventricular volume (VV) in patients with FTLD. METHODS Subjects with an FTLD cognitive syndrome were recruited from five centers using standard clinical diagnostic criteria for behavioral… CONTINUE READING

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