Brain and cerebrospinal fluid ionic composition and ventilation in acute hypercapnia.

@article{Nattie1980BrainAC,
  title={Brain and cerebrospinal fluid ionic composition and ventilation in acute hypercapnia.},
  author={E E Nattie},
  journal={Respiration physiology},
  year={1980},
  volume={40 3},
  pages={309-22}
}
  • E E Nattie
  • Published 1980 in Respiration physiology
Rats were exposed to 11% CO2 in air for 15 min or 3 h and measurements made of ventilation, CSF acid-base values, and blood, CSF and brain electrolytes. Brain tissue HCO3- was studied by performing CO2 titration curves of tissue homogenates in vitro, the upward displacement of these curves reflecting the non-physico-chemical buffer mechanisms prominent in sustained hypercapnia. At 15 min, the CO2 induced increase in [HCO3-] was accompanied in CSF by an equimolar increase in [Na+] and in brain… CONTINUE READING