Brain and cancer: The protective role of erythropoietin

@article{Buemi2005BrainAC,
  title={Brain and cancer: The protective role of erythropoietin},
  author={Michele Buemi and Chiara Caccamo and Lorena Nostro and Emanuela Cavallaro and Fulvio Floccari and Giovanni Grasso},
  journal={Medicinal Research Reviews},
  year={2005},
  volume={25}
}
Erythropoietin (Epo) is a pleiotropic agent, that is to say, it can act on several cell types in different ways. An independent system Epo/Epo receptor (EpoR) was detected in brain, leading to the hypothesis that this hormone could be involved in cerebral functions. Epo/EpoR expression changes during ontogenesis, thus indicating the importance of this system in neurodevelopment. Moreover, the hypoxia‐induced production of Epo in the adult brain suggests that it could exert a neurotrophic and… 

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