Brain and cancer: The protective role of erythropoietin

  title={Brain and cancer: The protective role of erythropoietin},
  author={M. Buemi and C. Caccamo and L. Nostro and E. Cavallaro and F. Floccari and G. Grasso},
  journal={Medicinal Research Reviews},
Erythropoietin (Epo) is a pleiotropic agent, that is to say, it can act on several cell types in different ways. An independent system Epo/Epo receptor (EpoR) was detected in brain, leading to the hypothesis that this hormone could be involved in cerebral functions. Epo/EpoR expression changes during ontogenesis, thus indicating the importance of this system in neurodevelopment. Moreover, the hypoxia‐induced production of Epo in the adult brain suggests that it could exert a neurotrophic and… Expand
Role of Erythropoietin in Cerebral Glioma: An Innovative Target in Neuro-Oncology.
The results of this study have shown that the EPO/EPOR complex might play a significant role in the aggressive behavior of high-grade gliomas and suggests a feasible role for EPO in the aggressiveness and progression of malignant glioma. Expand
Induction of Signalling in Non-Erythroid Cells by Pharmacological Levels of Erythropoietin
It is demonstrated that EPO, at pharmacological concentrations, can activate three major signalling cascades, viz. the Jak2/STAT5, Ras/ERK and PI3K/Akt pathways in non-small cell lung carcinoma (NSCLC) cell lines. Expand
Emerging technologies in the delivery of erythropoietin for therapeutics
The present review focuses on updating the information previously provided by similar reviews and recent experimental approaches presented to describe the advances in Epo drug delivery achieved in the last few years and future perspectives. Expand
Targeted Delivery of Erythropoietin Hybridized with Magnetic Nanocarriers for the Treatment of Central Nervous System Injury: A Literature Review
  • C. Hwang
  • Medicine
  • International journal of nanomedicine
  • 2020
Preclinical trials are required to increase the therapeutic bioavailability of erythropoietin nanocarriers and decrease the adverse effects (hematological complications, neurotoxicity, and cytotoxicity), especially of the Nanocarrier. Expand
The insulin-like growth factor system and its pleiotropic functions in brain.
In vitro studies have demonstrated that the IGF system promotes differentiation and proliferation and sustains survival, preventing apoptosis of neuronal and brain derived cells and studies of transgenic mice overexpressing components of the IGFsystem or mice with disruptions of the same genes have clearly shown thatThe IGF system plays a key role in vivo. Expand
Attenuation of cytogenetic effects by erythropoietin in human lymphocytes in vitro and P388 ascites tumor cells in vivo treated with irinotecan (CPT-11).
  • E. Digkas, D. Kareli, +5 authors T. Lialiaris
  • Medicine, Chemistry
  • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2010
Erythropoietin's protective action on human peripheral lymphocytes in vitro and P388 cells in vivo from the topoisomerase I inhibitor CPT-11, lead to propose it as a geno- and cytoprotective agent. Expand
In vitro and in vivo Cytogenetic Effects of Recombinant Human Erythropoietin on the Frequency of Sister Chromatid Exchanges Alone or in Combination with Mitomycin C
Erythropoietin acts protectively against the genotoxic potential of MMC, and this action may have clinical implications. Expand
Subretinal delivery of AAV2-mediated human erythropoietin gene is protective and safe in experimental diabetic retinopathy.
The ERG results showed that the retinal function remained unchanged for at least one year after subretinal injection of AAV2-CMV-hEPO virus, and it exerts long-term protective effects on diabetic retinas. Expand
The electronic structure of human erythropoietin as an aid in the design of oxidation-resistant therapeutic proteins.
  • F. Pichierri
  • Chemistry, Medicine
  • Bioorganic & medicinal chemistry letters
  • 2006
The electronic structure of human erythropoietin (HuEPO) has been investigated with the aid of quantum mechanical calculations. The results indicate that the protein is highly polarized and itsExpand
Erythropoietin in ophthalmology: A literature review
EPO has been used for the treatment of different ophthalmic conditions with promising results and further studies are needed to elaborate the role of EPO in management of ocular diseases. Expand


The Pleiotropic Effects of Erythropoietin in the Central Nervous System
The neurotrophic and neuroprotective function of Epo in different conditions of neuronal damage, such as hypoxia, cerebral ischemia, and subarachnoid hemorrhage, and the consequent possibility that rHuEpo therapy could soon be used in clinical practice to limit neuronal damage induced by these diseases. Expand
A Potential Role for Erythropoietin in Focal Permanent Cerebral Ischemia in Mice
  • M. Bernaudin, H. H. Marti, +4 authors E. Petit
  • Medicine
  • Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
  • 1999
The hypothesis that there is a continuous formation of Epo, with its corresponding receptor, during the active evolution of a focal cerebral infarct is supported and the Epo/Epo-R system might be implicated in the processes of neuroprotection and restructuring (such as angiogenesis and gliosis) after ischemia. Expand
EPO's Alter Ego: Erythropoietin Has Multiple Actions
The recent discovery of EPO‐Rs in breast tumor vasculature, while raising important questions about the possible effects of pharmacological doses of rHuEPO on tumor cells, also suggests that the receptors could provide a useful target for drugs attached to EPO. Expand
Identification of a neurotrophic sequence in erythropoietin.
Findings indicate that neural cells and not hematological cells respond to a peptide sequence within erythropoietin and suggests that Epo may have separate domains for neurotrophic and hematotrophic function. Expand
Erythropoietin regulates tumour growth of human malignancies.
The findings suggest that Epo is indispensable for the growth and viability of malignant tumour and also that the deprivation of Epo signalling may be a promising therapy for human malignancy. Expand
Effects of Erythropoietin on Neuronal Activity
The results suggest that EPO stimulates neuronal function and viability via activation of Ca2+ channels. Expand
Erythropoietin: Multiple Physiological Functions and Regulation of Biosynthesis
Novel functions ofEpo at these local sites and tissue-specific regulation of Epo production including a newly found potent regulator (estrogen) have been proposed, which rationalizes the specific functions of EpO produced by individual tissues. Expand
Detection of erythropoietin in human liquor: intrinsic erythropoietin production in the brain.
It is shown that immunoreactive EPO is present in ventricular cerebrospinal fluid of 5 patients with traumatic brain injuries, suggesting that EPO acts in a paracrine fashion in the central nervous system and might function as a protective factor against hypoxia-induced damage of neurons. Expand
Erythropoietin prevents neuronal apoptosis after cerebral ischemia and metabolic stress
  • A. Sirén, M. Fratelli, +12 authors P. Ghezzi
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 2001
Data suggest that inhibition of neuronal apoptosis underlies short latency protective effects of EPO after cerebral ischemia and other brain injuries, and the neurotrophic actions suggest there may be longer-latency effects as well. Expand
Production and processing of erythropoietin receptor transcripts in brain.
Describing the human EpoR transcript in brain and neuronal cells to determine its contribution in regulating the Epo response in brain suggests that in contrast to erythropoiesis, the neuroprotective effect of Epo and its receptor may require two molecular events: the induction ofEpo production by hypoxia and an increase inEpoR expression in neuronal cells resulting in increased sensitivity to Epo. Expand