Brain and blood concentrations of propofol after rapid intravenous injection in sheep, and their relationships to cerebral effects.

@article{Ludbrook1996BrainAB,
  title={Brain and blood concentrations of propofol after rapid intravenous injection in sheep, and their relationships to cerebral effects.},
  author={Guy L. Ludbrook and Richard N Upton and Cliff Grant and Elke C. Gray},
  journal={Anaesthesia and intensive care},
  year={1996},
  volume={24 4},
  pages={445-52}
}
The time-course of propofol concentrations in the blood and brain following rapid administration of three doses were examined using a sheep preparation and regional pharmacokinetic techniques. These were compared to the time-course of cerebral effects of propofol reported previously. There were marked differences between the time-course of propofol concentrations in arterial blood and the brain, with a close relationship between the time-course of brain concentrations and effects on depth of… CONTINUE READING