Brain alpha-synuclein accumulation in multiple system atrophy, Parkinson's disease and progressive supranuclear palsy: a comparative investigation.

@article{Tong2010BrainAA,
  title={Brain alpha-synuclein accumulation in multiple system atrophy, Parkinson's disease and progressive supranuclear palsy: a comparative investigation.},
  author={Junchao Tong and Henry Hei Wong and Mark Guttman and Lee Cyn Ang and Lysia S. Forno and Mitsunobu Shimadzu and Ali H. Rajput and Manfred D Muenter and Stephen J. Kish and Oleh Hornykiewicz and Yoshiaki Furukawa},
  journal={Brain : a journal of neurology},
  year={2010},
  volume={133 Pt 1},
  pages={172-88}
}
Alpha-synuclein is a major component of Lewy bodies and glial cytoplasmic inclusions, pathological hallmarks of idiopathic Parkinson's disease and multiple system atrophy, and it is assumed to be aetiologically involved in these conditions. However, the quantitative status of brain alpha-synuclein in different Parkinsonian disorders is still unresolved and it is uncertain whether alpha-synuclein accumulation is restricted to regions of pathology. We compared membrane-associated, sodium dodecyl… CONTINUE READING