Brain activity during distention of the descending colon in humans

  title={Brain activity during distention of the descending colon in humans},
  author={Toyohiro Hamaguchi and Michiko Kano and Hisashi Rikimaru and M. Kanazawa and Masatoshi Itoh and Kazuhiko Yanai and Shin Fukudo},
  journal={Neurogastroenterology \& Motility},
Abstract  Brain‐gut interaction is considered to be a major factor in the pathophysiology of irritable bowel syndrome. However, only limited information has been provided on the influence of gastrointestinal tract stimulation on the brain. Our aim in this study was to determine the specific regions of the brain that are responsible for visceral perception and emotion provoked by distention of the descending colon in humans. Fifteen healthy males aged 22 ± 1 participated in this study. Using a… 

Effects of Preceding Stimulation on Brain Activation in Response to Colonic Distention in Humans

By directly comparing different patterns of visceral stimuli, preceding visceral stimuli may affect neural sensitization and/or desensitization in humans, including elevated midbrain, insula, and midcingulate cortex.

Contributions of the Cerebellum to Disturbed Central Processing of Visceral Stimuli in Irritable Bowel Syndrome

Signs of anxiety and depression, which are frequently found in chronic pain conditions like IBS, modulate activation during visceral sensory signals not only in cortical and subcortical brain areas but also in the cerebellum.

Brain Activation Associated With Changes in Heart Rate, Heart Rate Variability, and Plasma Catecholamines During Rectal Distention

The results suggest that the right insula and the related body mapping regions may form the functional module of sympathetic arousal in response to gut stimulation.

Stress and visceral pain: Focusing on irritable bowel syndrome

Classical conditioned response of rectosigmoid motility and regional cerebral activity in humans

  • M. KanazawaM. Endo S. Fukudo
  • Biology, Psychology
    Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society
  • 2005
The hypothesis that the rectosigmoid motility becomes conditioned with anticipatory painful somatosensory stimulus and that characteristic brain areas become activated during anticipation is tested.

Cognitive therapy for irritable bowel syndrome is associated with reduced limbic activity, GI symptoms, and anxiety.

Relationship between sympathoadrenal and pituitary-adrenal response during colorectal distention in the presence of corticotropin-releasing hormone in patients with irritable bowel syndrome and healthy controls

There was a strong correlation between adrenaline and HRV upon CRH injection in controls, but not patients with IBS, and plasma adrenaline levels were shown to be associated with plasma ACTH levels in HCs injected with CRH during distention using structural equation modeling analysis.

Differential Activation in Amygdala and Plasma Noradrenaline during Colorectal Distention by Administration of Corticotropin-Releasing Hormone between Healthy Individuals and Patients with Irritable Bowel Syndrome

Exogenous CRH differentially sensitizes brain regions of the emotional-arousal circuitry within the visceral pain matrix to colorectal distention and synergetic activation of noradrenergic function in IBS patients and healthy individuals.

Brain activity following esophageal acid infusion using positron emission tomography.

Emotion-related brain areas were activated by esophageal acid stimulation, with strong activation of the orbitofrontal cortex found by subtraction analysis of the two second pH 1 infusions, with a significant increase of heartburn symptoms.



Gastric distention correlates with activation of multiple cortical and subcortical regions.

Symptomatic gastric distention activates structures implicated in somatic pain processing, supporting the notion of a common cerebral pain network.

Brain-gut response to stress and cholinergic stimulation in irritable bowel syndrome. A preliminary study.

The results suggest that patients with IBS have exaggerated responsivity of the gut and the brain to mental stress and cholinergic stimulation, and there is a possibility that these exaggerated responses are related.

A study of the cortical processing of ano-rectal sensation using functional MRI.

Anal and rectal sensation resulted in a similar pattern of cortical activation, including areas involved with spatial discrimination, attention and affect, and this explains the greater autonomic responses evoked by visceral sensation in comparison with somatic sensation.

Comparison of cortical potentials evoked by mechanical and electrical stimulation of the rectum

It is demonstrated that electrical rectal stimulation is a more reliable stimulus for recording CEPs, and the similarity of the morphology and interpeak latencies of the C EPs suggests that both stimuli are activating a similar network of cortical neurones.

Impact of corticotropin-releasing hormone on gastrointestinal motility and adrenocorticotropic hormone in normal controls and patients with irritable bowel syndrome

Human intestinal motility is probably modulated by exogenous CRH, and the brain-gut in IBS patients may have an exaggerated response to CRH.