Brain activation during cognitive stimulation with the Wisconsin Card Sorting Test — a functional MRI study on healthy volunteers and schizophrenics

  title={Brain activation during cognitive stimulation with the Wisconsin Card Sorting Test — a functional MRI study on healthy volunteers and schizophrenics},
  author={Hans Peter Volz and Christian Gaser and Frank H{\"a}ger and Reinhard Rzanny and H. Sauer},
  journal={Psychiatry Research: Neuroimaging},

Challenging the anterior attentional system with a continuous performance task: a functional magnetic resonance imaging approach

Abstract Combining the Continuous Performance Test (CPT) with a modern functional imaging technique provides a powerful tool for investigating neurophysiological processes in the human brain. There

Evaluation of a novel event-related parametric fMRI paradigm investigating prefrontal function

Working memory capacity in schizophrenia: a parametric fMRI study

Activation of the Prefrontal Cortex during the Wisconsin Card Sorting Test as Measured by Multichannel Near-Infrared Spectroscopy

These results directly confirmed that the PFC was activated during the Wisconsin Card Sorting Test in vivo by using the optical technique and suggested that the distribution of the activation in the P FC is different among healthy individuals.

Hypofrontality in neuroleptic-naive schizophrenic patients during the Wisconsin Card Sorting Test – a fMRI study

The results indicate that neuroleptic-naive schizophrenic patients show reduced activations in the right frontal and left temporal lobe, as well as in the left cerebellum, and suggest that “hypofrontality” is not caused by neuroleptics medication.

Applications of fMRI to Psychiatry

Functional magnetic resonance imaging refers to a noninvasive method to assess cortical activation by measuring changes in oxidation and regional blood flow, which capitalizes on the fact that in general, focal changes in neuronal activity are coupled closely to changes in CBF and CBV.

Functional MRI neuroanatomic correlates of the Hooper Visual Organization Test

The results indicate a general brain region or network in which VOT impairment, due to its visuospatial and object identification demands, is possible to be detected.



Functional magnetic resonance imaging of schizophrenic patients and comparison subjects during word production.

OBJECTIVE This study was undertaken to test the feasibility of using functional magnetic resonance imaging (MRI) to examine changes in cortical activation in response to verbal tasks in two brain

Altered modulation of prefrontal and subcortical brain activity in newly diagnosed schizophrenia and schizophreniform disorder. A regional cerebral blood flow study.

A significant relative activation deficit in the left inferior-prefrontal region was revealed during the Wisconsin Card Sorting Test in the patient group and the patients had impaired striatal suppression on the left side during the cognitive task.

Physiologic dysfunction of dorsolateral prefrontal cortex in schizophrenia. II. Role of neuroleptic treatment, attention, and mental effort.

The data suggest that DLPFC dysfunction in schizophrenia is independent of medication status and not determined simply by state factors such as attention, mental effort, or severity of psychotic symptoms.

Evidence of dysfunction of a prefrontal-limbic network in schizophrenia: a magnetic resonance imaging and regional cerebral blood flow study of discordant monozygotic twins.

The more an affected twin differed from the unaffected twin in left hippocampal volume, the more they differed in prefrontal physiological activation during the Wisconsin Card Sorting Test, consistent with the notion that schizophrenia involves pathology of and dysfunction within a widely distributed neocortical-limbic neural network.

The left medial temporal region and schizophrenia. A PET study.

Psychopathology and neurophysiology exhibited high correlations in the left medial temporal region, mesencephalic, thalamic and left striatal structures, and the prefrontal component appears to be critically dependent on the behavioural subsyndrome.

Hypofrontality in neuroleptic-naive patients and in patients with chronic schizophrenia. Assessment with xenon 133 single-photon emission computed tomography and the Tower of London.

The results suggest that hypofrontality is related to negative symptoms and is not a long-term effect of neuroleptic treatment or of chronicity of illness.