Brain acetylcholinesterase activity in mild cognitive impairment and early Alzheimer's disease.

@article{Rinne2003BrainAA,
  title={Brain acetylcholinesterase activity in mild cognitive impairment and early Alzheimer's disease.},
  author={Juha O. Rinne and Valtteri Kaasinen and Tarja J{\"a}rvenp{\"a}{\"a} and Kjell N{\aa}gren and Anne Roivainen and Meixiang Yu and Vesa Oikonen and Timo J I Kurki},
  journal={Journal of neurology, neurosurgery, and psychiatry},
  year={2003},
  volume={74 1},
  pages={113-5}
}
OBJECTIVE Brain acetylcholinesterase activity was determined in healthy controls and in patients with mild cognitive impairment and early Alzheimer's disease. METHODS A specific acetylcholinesterase tracer, [methyl-(11)C]N-methyl-piperidyl-4-acetate ([(11)C]MP4A), and a three dimensional PET system with magnetic resonance coregistration were used for imaging. RESULTS There was a significant difference in the acetylcholinesterase activity in the hippocampus between the groups (p = 0.03), the… CONTINUE READING

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Neuroanatomy of cholinesterases in the normal human brain and in Alzheimer’s disease

  • M. Mesulam
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