Brain access and anticonvulsant efficacy of carbamazepine, lamotrigine, and felbamate in ABCC2/MRP2-deficient TR- rats.

@article{Potschka2003BrainAA,
  title={Brain access and anticonvulsant efficacy of carbamazepine, lamotrigine, and felbamate in ABCC2/MRP2-deficient TR- rats.},
  author={Heidrun Potschka and Maren Fedrowitz and Wolfgang L{\"o}scher},
  journal={Epilepsia},
  year={2003},
  volume={44 12},
  pages={1479-86}
}
PURPOSE Different adenosine triphosphate (ATP)-driven multidrug transporters have been described to be expressed in the luminal membrane of blood-brain barrier (BBB) endothelial cells. At this site, multidrug transporters have been suggested to restrict penetration of drugs into the brain. Increasing evidence suggests that overexpression of different multidrug transporters occurs in the region of the epileptic focus of pharmacoresistant epilepsy patients. Based on the assumption that… CONTINUE READING

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