Brain abnormalities in early-onset schizophrenia spectrum disorder observed with statistical parametric mapping of structural magnetic resonance images.

@article{Sowell2000BrainAI,
  title={Brain abnormalities in early-onset schizophrenia spectrum disorder observed with statistical parametric mapping of structural magnetic resonance images.},
  author={Elizabeth R. Sowell and Jennifer Levitt and Paul M. Thompson and Colin J. Holmes and Rebecca E. Blanton and David Kornsand and Rochelle Caplan and James Thomas Mccracken and Robert Asarnow and Arthur W. Toga},
  journal={The American journal of psychiatry},
  year={2000},
  volume={157 9},
  pages={
          1475-84
        }
}
OBJECTIVE The purpose of this study was to assess neuroanatomic abnormalities in children and adolescents with childhood-onset schizophrenia by using whole-brain voxel-based morphometric analyses. Previous volumetric studies of brain abnormalities in childhood-onset schizophrenia have revealed anomalies similar to those in subjects with adult-onset schizophrenia. Specifically, low cerebral volume, high ventricular volume, and thalamic, basal ganglia, callosal, and temporal lobe abnormalities… CONTINUE READING

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