Brain Testosterone Deficiency Leads to Down-Regulation of Mitochondrial Gene Expression in Rat Hippocampus Accompanied by a Decline in Peroxisome Proliferator-Activated Receptor-γ Coactivator 1α Expression

@article{Hioki2013BrainTD,
  title={Brain Testosterone Deficiency Leads to Down-Regulation of Mitochondrial Gene Expression in Rat Hippocampus Accompanied by a Decline in Peroxisome Proliferator-Activated Receptor-γ Coactivator 1α Expression},
  author={Takeshi Hioki and Shunya Suzuki and Megumi Morimoto and Tsuneo Masaki and Ryuichi Tozawa and Shigeru Morita and Takashi Horiguchi},
  journal={Journal of Molecular Neuroscience},
  year={2013},
  volume={52},
  pages={531-537}
}
Age-related decrease of testosterone levels in blood and brain is believed to be associated with neurodegenerative diseases such as Alzheimer’s disease. However, the effect of testosterone on brain function is not well understood. Therefore, we investigated the impact of testosterone deprivation on mitochondrial gene expression in the brain of male gonadectomized (GDX) rats. We found that peripheral castration led to testosterone deficiency in the brain and caused a significant reduction in… CONTINUE READING
5 Extracted Citations
35 Extracted References
Similar Papers

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 35 references

Similar Papers

Loading similar papers…