Brain TRPV1: a depressing TR(i)P down memory lane?

  title={Brain TRPV1: a depressing TR(i)P down memory lane?},
  author={Vincenzo Di Marzo and Gabriella Gobbi and Arpad Szallasi},
  journal={Trends in pharmacological sciences},
  volume={29 12},
On sensory neurons, the capsaicin receptor TRPV1 (transient receptor potential, vanilloid subfamily, member 1) functions as a molecular integrator of noxious stimuli and represents a novel target for analgesic drugs. The presence of TRPV1 in the brain is now well established but, despite intensive research, its function is only beginning to be understood. New evidence implies an unexpected role for hippocampal TRPV1 in neuropsychiatric disorders. For instance, it was hypothesized that the… CONTINUE READING