Brain Stimulation Reward

  title={Brain Stimulation Reward},
  author={Peter Shizgal},

On the Similarity Between the Reinforcing and the Discriminative Properties of Intracranial Self-Stimulation

It is concluded that rats integrate response requirements as part of the reinforcement tradeoff function, but the response cost is not integrated into the discriminative function of ICSS.

CB1-Dependent Long-Term Depression in Ventral Tegmental Area GABA Neurons: A Novel Target for Marijuana

A novel form of glutamatergic synaptic plasticity in VTA GABA neurons is identified, a currently understudied cell type that is critical for the brain's reward circuit, and how Δ9-tetrahydrocannabinol occludes this plasticity is identified.



On the neural computation of utility: implications from studies of brain stimulation reward

This chapter addresses the relationships between brain stimulation reward (BSR), the perceptual, interval timing, and evaluative channels, and the variants of utility proposed by Kahneman and his coworkers on the basis of their studies of evaluation and choice in human subjects.

Addictive drugs and brain stimulation reward.

  • R. Wise
  • Biology, Psychology
    Annual review of neuroscience
  • 1996
The reward-potentiating effects of amphetamine and opiates are associated with central sites of action where these drugs also have their direct rewarding effects, suggesting common mechanisms for drug reward per se and for drug potentiation of brain stimulation reward.

At What Stage of Neural Processing Does Cocaine Act to Boost Pursuit of Rewards?

A new conceptual framework and new methodology for determining the stage(s) of neural processing at which drugs, lesions and physiological manipulations act to influence reward-seeking behavior is introduced, challenging the long-standing view that cocaine increases the sensitivity of brain reward circuitry.

Brain dopamine and reward.

While the evidence is strong that dopamine plays some fundamental and special role in the rewarding effects of brain stimulation, psychomotor stimulants, opiates, and food, the exact nature of that

Self-Stimulation of the Brain

It is reasonable to hope that eventually it will be possible to control the reward systems pharmacologically in cases where behavior disorders seem to result from deficits or surfeits of positive motivation.

Dissociation of dopamine release in the nucleus accumbens from intracranial self-stimulation

Dopamine may be a neural substrate for novelty or reward expectation rather than reward itself, and evoked dopamine release is actually diminished during intracranial self-stimulation.

Mapping the Neural Substrate Underlying Brain Stimulation Reward with the Behavioral Adaptation of Double-Pulse Methods

Behavioral adaptations of double-pulse methods have been employed to unveil the electrophysiological and anatomical characteristics of neural networks of known function to provide a means of discriminating between the neurons underlying this behavior from other cells activated by the stimulating electrode.

Dopamine and reward: The anhedonia hypothesis 30 years on

  • R. Wise
  • Psychology, Biology
    Neurotoxicity Research
  • 2009
The anhedonia hypothesis was intended to draw the attention of psychiatrists to the growing evidence that dopamine plays a critical role in the objective reinforcement and incentive motivation associated with food and water, brain stimulation reward, and psychomotor stimulant and opiate reward.

On the Neural Computation of Utility

It is argued that the artificial and natural rewards are evaluated in a common currency, represented in an aggregate firing-rate code, which would make it possible for the synchronous, spatially contiguous pattern of neural firing induced by the electrode to simulate a signal normally produced by asynchronous, spatually distributed activity.