Brain State Is a Major Factor in Preseizure Hippocampal Network Activity and Influences Success of Seizure Intervention.

@article{Ewell2015BrainSI,
  title={Brain State Is a Major Factor in Preseizure Hippocampal Network Activity and Influences Success of Seizure Intervention.},
  author={Laura A Ewell and Liang Liang and Caren Armstrong and Ivan Soltesz and Stefan Leutgeb and Jill K Leutgeb},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2015},
  volume={35 47},
  pages={15635-48}
}
UNLABELLED Neural dynamics preceding seizures are of interest because they may shed light on mechanisms of seizure generation and could be predictive. In healthy animals, hippocampal network activity is shaped by behavioral brain state and, in epilepsy, seizures selectively emerge during specific brain states. To determine the degree to which changes in network dynamics before seizure are pathological or reflect ongoing fluctuations in brain state, dorsal hippocampal neurons were recorded… CONTINUE READING
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carinic excitation of parvalbuminpositive interneurons contributes to the severity of pilocarpineinduced seizures

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